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Published on: July 27, 2018
The placenta growth factor in skin angiogenesis
Teresa Odorisio1, Francesca Cianfarani, Cristina Maria Failla
1Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata, I.D.I.-I.R.C.C.S., Via Dei Monti di Creta, 104, 00167 Rome, Italy.
Journal of Dermatological Science
|October 12, 2005
Summary
Placenta growth factor (PlGF) promotes skin blood vessel formation and wound healing. PlGF delivery can create stable blood vessels without impacting lymphatic function, suggesting therapeutic potential.
Area of Science:
- Vascular biology
- Dermatology
- Cancer research
Background:
- Placenta growth factor (PlGF) is a vascular endothelial growth factor (VEGF) family member.
- PlGF promotes pathological angiogenesis and is upregulated during skin wound healing.
- PlGF expression in melanoma is linked to tumor growth.
Purpose of the Study:
- To investigate the role of PlGF in skin angiogenesis.
- To evaluate the therapeutic potential of PlGF for skin repair and vascularization.
Main Methods:
- Analysis of a transgenic mouse model with constitutive PlGF expression in keratinocytes.
- Delivery of PlGF to the skin using an adenoviral vector.
- Assessment of blood and lymphatic vessel formation and functionality.
Main Results:
- Constitutive PlGF expression induced robust skin angiogenesis during embryonic and post-natal development.
- Adenoviral PlGF delivery resulted in large, stable blood vessel formation.
- PlGF delivery did not impair lymphatic vessel functionality, unlike VEGF.
Conclusions:
- PlGF possesses potent angiogenic properties in the skin.
- PlGF can be a potential therapeutic agent for modulating skin angiogenesis.
- PlGF offers a distinct therapeutic avenue compared to VEGF for vascularization without lymphatic compromise.
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