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Ancestral state reconstructions for genomes.

Christos A Ouzounis¹

¹Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK. ouzounis@ebi.ac.uk

Current Opinion in Genetics & Development

|October 12, 2005

Summary

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Phylogenetic analysis now includes entire genomes, enabling reconstruction of species and ancestral genome history. This genomic evolution approach may allow future synthesis of ancient genomes.

Area of Science:

Evolutionary biology
Genomics
Bioinformatics

Background:

Phylogenetic analysis traditionally focused on molecular evolution and gene histories.
The field is expanding to genomic evolution, analyzing entire genomes.

Purpose of the Study:

To explore the application of phylogenetic analysis to entire genomes.
To reconstruct species history and ancestral genome states.

Main Methods:

Utilizing genomes as phylogenetic characters.
Applying parsimony reconstructions to genome information.

Main Results:

Construction of phylogenetic trees based on genome data.
Quantification of processes shaping genome content.

Related Experiment Videos

Reconstruction of ancestral genome structure and function.

Conclusions:

Genomic evolution allows for detailed reconstruction of evolutionary history.
Future potential includes synthesizing ancestral genomes and creating a 'Jurassic database'.