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Historical trends in reported survival rates in patients with hypertrophic cardiomyopathy

P M Elliott1, J R Gimeno, R Thaman

  • 1The Heart Hospital, University College London, London, UK. perry.elliott@uclh.org

Heart (British Cardiac Society)
|October 12, 2005
PubMed

Insights

Survival rates for hypertrophic cardiomyopathy (HCM) patients have improved significantly. Modern HCM cohorts show fewer severe complications and lower sudden death rates compared to earlier studies.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex genetic heart disease.
  • Understanding the natural history and survival rates of HCM is crucial for patient management.
  • Previous studies have reported varying survival outcomes in HCM cohorts.

Purpose of the Study:

  • To determine the range of survival rates in hypertrophic cardiomyopathy (HCM) patients.
  • To compare the natural history of a contemporary HCM cohort with historical data.
  • To identify trends in HCM complications and outcomes over time.

Main Methods:

  • Evaluation of 956 adult HCM patients (age >= 16) using ECG, Holter, exercise testing, and echocardiography.
  • Comparison of patient characteristics and survival data with published natural history studies (1960-2003).
  • Analysis of outcomes including death, cardiac transplantation, sudden cardiac death, heart failure, and stroke.

Main Results:

  • The annual rate of sudden death or implantable cardioverter-defibrillator discharge was 1.02%.
  • Annual rates for heart failure death/transplantation and stroke-related death were 0.55% and 0.07%, respectively.
  • Contemporary HCM cohorts (last 10 years) showed larger study sizes, lower rates of severe functional limitation (NYHA class III/IV), and reduced septal myotomy-myectomy procedures compared to earlier reports. Published sudden death rates were also lower.

Conclusions:

  • Survival rates in hypertrophic cardiomyopathy (HCM) cohorts have progressively improved over the past 40 years.
  • In the modern era, the prevalence of disease-related complications is similar across reporting centers.
  • These findings highlight advancements in HCM management and patient outcomes.
Abstract

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