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ERTargetDB: an integral information resource of transcription regulation of estrogen receptor target genes

V X Jin1, H Sun, T T Pohar

  • 1Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, 420 W 12th Avenue, TMRF 524A, Columbus, Ohio 43210, USA.

Journal of Molecular Endocrinology
|October 12, 2005
PubMed

Insights

Researchers developed ERTargetDB, a database integrating estrogen receptor (ER) target gene information. This resource aids in understanding ER gene regulation and cancer development, crucial for endocrinology research.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Bioinformatics

Background:

  • The estrogen receptor (ER) is vital for reproductive and non-reproductive functions.
  • ER malignancies are linked to breast and prostate cancers, necessitating study of ER target gene regulation.

Purpose of the Study:

  • To create ERTargetDB, a comprehensive database integrating published ER target gene information.
  • To provide researchers easy access to ER target genes and their promoter regulatory mechanisms.

Main Methods:

  • Integrated data from various publications and databases.
  • Included experimentally verified estrogen response elements (EREs) and tethering sites.
  • Incorporated data from chromatin immunoprecipitation and gene expression microarrays, alongside computational predictions.

Main Results:

  • The current ERTargetDB version contains 40 genes with verified EREs, 32 verified ERE tethering sites.
  • Includes 40 genes from ChIP-microarray, 381 from gene expression microarray, and 2948 from computational prediction.
  • Provides an integrated resource for direct ER target genes.

Conclusions:

  • ERTGDB serves as a valuable information resource for the endocrinology research community.
  • Facilitates investigation into gene regulation and supports the development of computational tools for ER target gene prediction.

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