Left ventricular assessment in myocardial infarction: the VALIANT registry
Adrian F Hernandez1, Eric J Velazquez, Scott D Solomon
1Division of Cardiology, Department of Medicine, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27715, USA.
Insights
Left ventricular assessment after myocardial infarction (MI) was often missed, even in heart failure (HF) patients. Performing this evaluation improved care quality and reduced in-hospital mortality for MI patients.
Area of Science:
- Cardiology
- Clinical Outcomes Research
- Healthcare Quality Improvement
Background:
- Echocardiography and cardiac catheterization are key for evaluating left ventricular (LV) function post-myocardial infarction (MI).
- The frequency of LV assessment and its impact on care quality in MI patients, particularly those with heart failure (HF), remains unclear.
Purpose of the Study:
- To determine the utilization rates of echocardiography and cardiac catheterization for LV assessment in MI patients.
- To investigate the association between LV assessment and the quality of care provided, including discharge medications and in-hospital outcomes.
Main Methods:
- Analysis of patients from the Valsartan in Acute Myocardial Infarction (VALIANT) registry, stratified by presence (n=1423) or absence (n=3968) of heart failure (HF).
- Comparison of LV assessment rates and baseline characteristics between HF and non-HF groups.
- Evaluation of the link between LV assessment and discharge medications, and in-hospital outcomes using multivariable and propensity analyses.
Main Results:
- 22.6% of HF patients and an unspecified percentage of non-HF patients did not undergo LV assessment.
- Patients with LV assessment received guideline-recommended medications more frequently.
- LV assessment was significantly associated with reduced in-hospital mortality in both HF (aOR 0.45) and non-HF (aOR 0.30) groups, an association persisting after excluding early deaths.
Conclusions:
- Left ventricular assessment is underutilized in acute myocardial infarction patients, including those with heart failure.
- Performing LV assessment is linked to improved quality of care and better in-hospital survival rates for myocardial infarction patients.
Background:
How often echocardiography and cardiac catheterization are used to evaluate left ventricular (LV) function in patients with myocardial infarction (MI) and how they are associated with quality of care is unknown.
Methods:
Patients with MI in the Valsartan in Acute Myocardial Infarction (VALIANT) registry were divided into those with (n = 1423) and without (n = 3968) heart failure (HF), and the use of either echocardiography or cardiac catheterization for LV assessment in each group was compared along with associated baseline characteristics. We evaluated the association between LV assessment and discharge medications. Using a multivariable model with a propensity analysis, we evaluated the association of LV assessment with in-hospital outcomes.
Results:
Of the patients with HF, 322 (22.6%) had no LV assessment. Patients with HF with LV assessment were discharged more frequently under treatment with aspirin (81.3% vs 70.0%; P<.001), beta-blockers (65.6% vs 56.4%; P = .008), clopidogrel (30.4% vs 14.0%; P<.001), and statins (45.9% vs 34.2%; P<.001). Patients without HF who underwent LV assessment were discharged more frequently under treatment with an angiotensin-converting enzyme inhibitor (53.8% vs 41.5%; P<.001). After adjustment for regional use, other covariates, and revascularization, LV assessment was associated with lower in-hospital mortality in patients with HF (adjusted odds ratio [OR], 0.45; P<.001) and in patients without HF (adjusted OR, 0.30; P<.001). After excluding deaths during the first 2 days, LV assessment remained associated with lower mortality in patients with HF (adjusted OR, 0.59; P = .03) and in patients without HF (adjusted OR, 0.41; P<.001).
Conclusion:
Left ventricular assessment was frequently not performed during the in-hospital stay of patients with acute MI, including those with clinical HF, and its use was associated with better quality of care.
Related Concept Videos
Acute Coronary Syndrome III: Diagnostic Studies
Cardiomyopathy II: Dilated Cardiomyopathy
Mitral Valve Prolapse II: Assessment and Management
Mitral Stenosis IV: Nursing Management
Cardiomyopathy V: Interprofessional Care


