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Updated: Aug 15, 2026
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Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
Published on: December 8, 2023
Progress in hematopoietic stem cell transplantation in multiple myeloma
1Department of Medicine, Karolinska Institute, Huddinge Karolinska University Hospital, Stockholm, Sweden. gosta.gahrton@medhs.ki.se
Current Opinion in Hematology
|October 12, 2005
Summary
Autologous stem cell transplant is the primary choice for multiple myeloma, but not curative. Allogeneic transplantation shows promise in trials for improved outcomes with new methods and targeted drugs.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Multiple myeloma treatment has evolved significantly.
- Hematopoietic stem cell transplantation (HSCT) plays a crucial role.
Purpose of the Study:
- To evaluate the roles of autologous and allogeneic HSCT in multiple myeloma.
- To assess recent advancements impacting patient outcomes.
Main Methods:
- Review of current literature on autologous and allogeneic HSCT for multiple myeloma.
- Analysis of conditioning regimens, stem cell sources, and transplant strategies.
Main Results:
- Autologous HSCT with melphalan conditioning and peripheral blood stem cells is standard.
- Tandem autologous transplants improve outcomes for non-complete responders.
- Allogeneic HSCT reduces relapse but has higher mortality; reduced-intensity conditioning lowers mortality but increases relapse.
- Donor lymphocyte infusions show inconclusive survival results for relapsed disease.
Conclusions:
- Autologous HSCT remains the first-line treatment for most myeloma patients, though not curative.
- Allogeneic HSCT warrants further research in clinical trials, focusing on novel conditioning, graft-versus-myeloma effects, and combination therapies.
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