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Updated: Aug 15, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
[Migraine update]
Hisanori Kowa1, Takao Takeshima, Kenji Nakashima
1Department of Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine.
Abstract:
Migraine is one of the common diseases suffering 8.4 million patients in Japan. The pathophysiology of migraine remains unclear. The genetic and basic studies of the familial hemiplegic migraine, a specific subtype of migraine with aura, have demonstrated the dysfunction of mutant brain-expressed calcium ion channel and/or the Na+/K+ ion transporter and suggested the association between cortical spreading depression (CSD) and migraine with aura. It is suggested that the CSD, neurogenic inflammation and vasodilatation caused by unknown triggers may activate the 'brainstem migraine generator' and amplified back way. In consequence, headache and/or aura will be appeared and strengthened. Our etiological data of headache in Daisen located in Western Japan clarified as follows; 1) Overall prevalence of migraine in Daisen was 6.0%. Women observed a 5.9-fold higher risk of migraine than men. 2) Fatigue, mental stress, and lack of sleep were the main headache triggers. 3) Only 7.3% of those with migraine with aura and 5.3% of those with migraine without aura had consulted a physician. 4) Migraineurs consume significantly more fatty/oily foods, coffee, and tea than nonheadache subjects of the same community. Migraineurs consume significantly fewer fish than nonheadache residents. As a conclusion, only a few Japanese migraineurs receive benefits of medical services and recent advances of headache medicine. The Japanese guideline for chronic headache treatment has declared in 2002. The International Classification of headache disorders has reedited to the 2nd edition. Public education concerning headaches is one of the most urgent issues in Japan.
Insights
Migraine affects millions in Japan, with triggers including stress and poor sleep. Few seek medical help, highlighting a need for public education on headache management and treatment advances.
Area of Science:
- Neurology
- Epidemiology
- Genetics
Context:
- Migraine is a prevalent neurological disorder impacting millions globally.
- The exact pathophysiology of migraine, particularly migraine with aura, involves complex mechanisms like cortical spreading depression (CSD) and ion channel dysfunction.
- Familial hemiplegic migraine studies suggest genetic links to ion transport and CSD.
Purpose:
- To investigate the prevalence, triggers, and healthcare-seeking behaviors of migraineurs in Daisen, Western Japan.
- To explore dietary patterns associated with migraine in the Japanese population.
- To identify gaps in medical service utilization for migraine patients in Japan.
Summary:
- Migraine prevalence in Daisen was 6.0%, with women at higher risk.
- Key triggers identified were fatigue, mental stress, and lack of sleep.
- Dietary patterns showed increased consumption of fatty foods, coffee, and tea, and decreased fish intake among migraineurs.
- Low rates of physician consultation (7.3% for migraine with aura, 5.3% for migraine without aura) were observed.
- The study highlights that few Japanese migraineurs benefit from current medical services and advances in headache medicine.
Impact:
- Findings underscore the significant underutilization of medical services by Japanese migraineurs.
- Identifies specific dietary patterns and lifestyle factors associated with migraine in Japan.
- Emphasizes the urgent need for public education on headache disorders and available treatments in Japan.
- Provides etiological data crucial for developing targeted public health interventions and improving migraine management strategies.
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