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Updated: Aug 15, 2026

The Examination of Peroxidase-Positive Leukocytes in Semen
Published on: January 19, 2024
[Detection of sexually transmitted pathogens in patients with hematospermia]
Shay Golan1, Elena Slomov, Zipi Kra-Oz
1The Bruce Rappaport Faculty of Medicine, Technion, Haifa.
Background:
Although the current literature attributes most cases of hematospermia to an infectious agent, identification of the specific pathogens involved has been limited.
Objective:
To determine the prevalence of different pathogens, in patients presenting with hematospermia to our sexually transmitted disease clinic.
Patients And Methods:
We retrospectively examined the laboratory results of 30 patients who presented to our clinic with hematospermia after other non-infectious pathologies had been excluded by a referring physician. Firstly, void urine samples as well as genitourinary and serum specimens were tested for Herpes simplex, Chlamydia trachomatis and Ureaplasma urealyticum. Standard bacterial cultures were also performed.
Results:
In 12 of the 18 patients a possible pathogenic cause for the hematospermia was found. Evidence for Herpes simplex virus (Type 2) was found in 5 of the patients (16.6%), for Chlamydia trachomatis in 3 patients (10%) and for Ureaplasma urealyticum in 2 of the patients. Enterococcus fecalis was detected in 2 (6.6%) of the patients and in 1 patient Herpes simplex virus (Type 1) antigen and antibodies were detected. In all cases in which evidence of a pathogen was identified, the appropriate antimicrobial agent was administered, with recurrence in two patients only.
Conclusions:
Recent advances in microbiologic diagnostic techniques have facilitated the detection of pathogens in patients with hematospermia, thereby enhancing the efficacy of treatment.
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