Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transgenic animals: current and alternative strategies.

A W Chan1

  • 1Oregon Regional Primate Research Center, Oregon Health Sciences University, Beaverton, Oregon 97006, USA. chana@ohsu.edu

Cloning
|October 13, 2005
PubMed
Summary

Creating transgenic animals requires efficient gene delivery. Recent advancements in cloning and new gene delivery systems are improving transgenic livestock production, overcoming previous barriers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing Interfractional Stability of Heart Dose Among Three Breath-Hold Radiotherapy Techniques in Breast Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Reporting of randomized controlled trial abstracts in dermatology journals according to CONSORT guidelines.

The British journal of dermatology·2021
Same author

A descriptive evaluation of resident prescription writing errors and self-perceived learning needs in dermatology.

Clinical and experimental dermatology·2021
Same author

Impact of setup and range uncertainties on TCP and NTCP following VMAT or IMPT of oropharyngeal cancer patients.

Physics in medicine and biology·2019
Same author

Outcomes of salvage radiotherapy for recurrent prostate cancer after radical prostatectomy.

Hong Kong medical journal = Xianggang yi xue za zhi·2018
Same author

The effects of global warming on allergic diseases.

Hong Kong medical journal = Xianggang yi xue za zhi·2018

Area of Science:

  • Transgenic animal technology
  • Gene delivery systems
  • Livestock improvement

Background:

  • Transgenic animal technology offers unique solutions in life sciences, impacting biomedical research and commercial interests.
  • Efficient and reliable gene delivery systems are crucial for creating transgenic animals, but traditional methods like pronuclear microinjection show low efficiency in livestock (<1%).

Purpose of the Study:

  • To review current gene delivery strategies for creating transgenic animals.
  • To explore various approaches for enhancing transgenic efficiency, particularly in large animals.

Main Methods:

  • Review of existing literature on gene delivery systems and transgenic animal production.
  • Analysis of recent advancements in cloning technology and their impact on transgenic efficiency.

Main Results:

  • Pronuclear microinjection, while effective in mice, has limited success rates in livestock.
  • Recent breakthroughs in cloning technology have enabled highly efficient production of transgenic livestock.
  • Novel gene delivery systems are emerging, fostering enthusiasm and unique applications in the field.

Conclusions:

  • Advancements in cloning and gene delivery mark a new era for transgenic technology, especially in large animals.
  • Continued research into efficient gene delivery strategies is essential to overcome existing barriers and expand applications.

Related Experiment Videos