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Related Experiment Videos

Device-related infections: a review.

Donald C Vinh1, John M Embil

  • 1Infectious Diseases and Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.

Journal of Long-Term Effects of Medical Implants
|October 13, 2005
PubMed
Summary

Device-related infections pose significant risks, leading to complications and challenging treatment. Understanding pathogenesis and implementing timely management are crucial for patient outcomes.

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Area of Science:

  • Infectious Diseases
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Surgically implanted devices improve quality of life but risk infection.
  • Device-related infections cause significant morbidity, mortality, and healthcare costs.
  • Lack of standardized definitions and studies complicates diagnosis and management.

Purpose of the Study:

  • To review definitions, microbiology, pathogenesis, and management of device-related infections.
  • To discuss infections associated with various implanted devices (neurosurgical, cardiac, orthopedic, etc.).
  • To highlight diagnostic challenges and treatment strategies, including salvage therapy and suppressive antimicrobial therapy.

Main Methods:

  • Literature review of device-related infections.
  • Analysis of pathogenesis, including microbial colonization and biofilm formation.
  • Discussion of diagnostic criteria and management guidelines for various implant types.

Main Results:

  • Device infections are characterized by microbial colonization and biofilm formation, rendering antibiotics less effective.
  • Clinical manifestations vary by pathogen and device component.
  • Prolonged antibiotic therapy and device removal are common, with limited indications for salvage therapy.

Conclusions:

  • Effective management requires understanding infection pathogenesis and timely diagnosis.
  • Tailored antimicrobial therapy and surgical intervention are often necessary.
  • Alternative strategies like suppressive therapy may be considered for non-surgical candidates.

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