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Updated: Aug 15, 2026

Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes
Published on: June 16, 2011
Activation-induced cell death in T cells and autoimmunity
Jian Zhang1, Xuemei Xu, Yong Liu
1Departments of Orthopedic Surgery and Immunology/Microbiology, Rush University Medical Center, Chicago, IL 60612, USA. jianz52@hotmail.com
Abstract:
Activation-induced cell death (AICD), which results from the interaction between Fas and Fas ligand, is responsible for maintaining tolerance to self-antigen. A defect in AICD may lead to development of autoimmunity. During the last several years, much progress has been made in understanding the mechanism(s) of AICD and its potential role in the pathogenesis of autoimmune diseases. In this review, we summarize the most recent progress on the regulation of the susceptibility of T cells to AICD and its possible involvement in autoimmune diseases.
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