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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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[Graves' disease in preschool children]
A Coca Pérez1, E Colino Alcol, M López Capapé
1Servicio de Pediatría, Hospital Ramón y Cajal, Madrid, Spain. pdacoca@hotmail.com
Anales De Pediatria (Barcelona, Spain : 2003)
|October 13, 2005
Summary
Graves
Area of Science:
- Pediatric Endocrinology
- Thyroidology
Background:
- Graves' disease is a leading cause of hyperthyroidism in children.
- It is exceptionally rare in preschool-aged children.
Observation:
- This study details four preschool girls diagnosed with Graves' disease.
- Presenting symptoms included tachycardia, diarrhea, developmental delay, and thyroid nodules.
- Ophthalmic manifestations were notably absent in all cases.
Findings:
- All patients exhibited elevated free T3 and T4 levels with suppressed TSH.
- Thyroid-stimulating immunoglobulins were detected in three patients.
- Two patients achieved complete remission with carbimazole treatment over five years.
Implications:
- Early diagnosis of Graves' disease in young children is crucial.
- The absence of ophthalmic signs does not rule out the condition.
- Carbimazole is an effective treatment option with a favorable safety profile in this age group.
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