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Published on: August 15, 2019
Directional positive selection on an allele of arbitrary dominance
Kosuke M Teshima1, Molly Przeworski
1Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA. kteshima@uchicago.edu
Abstract:
Most models of positive directional selection assume codominance of the beneficial allele. We examine the importance of this assumption by implementing a coalescent model of positive directional selection with arbitrary dominance. We find that, for a given mean fixation time, a beneficial allele has a much weaker effect on diversity at linked neutral sites when the allele is recessive.
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