Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic

Edward D Levin1, F Joseph McClernon, Amir H Rezvani

  • 1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box #3412, Durham, NC 27710, USA. edlevin@duke.edu

Psychopharmacology
|October 13, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Persisting neurobehavioral consequences of gestational exposure to cadmium and benzo[a]pyrene in rats.

Neurotoxicology and teratology·2025
Same author

Pentilludin reduces rat amphetamine and remifentail self-administration with good pharmacologic and toxicologic profiles.

bioRxiv : the preprint server for biology·2025
Same author

Low dose nicotine administration improves attentional performance in rats but is not blocked by nicotinic antagonists.

Pharmacology, biochemistry, and behavior·2025
Same author

Neurotoxicology and public health issues of cannabis and cannabinoids.

Neurotoxicology·2024
Same author

Persisting neurobehavioral consequences of daily or intermittent paternal cannabis administration in F1 and F2 Rats.

Neurotoxicology·2024
Same author

Embryonic exposures to cadmium and PAHs cause long-term and interacting neurobehavioral effects in zebrafish.

Neurotoxicology and teratology·2024
Same journal

GlyT1 inhibition enhances working memory in the mouse TUNL task and normalizes NMDA antagonist-induced network activity.

Psychopharmacology·2026
Same journal

Effects of repeated treatment with opioids that vary in mu opioid receptor efficacy on pain-depressed locomotor behavior in mice.

Psychopharmacology·2026
Same journal

Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB<sub>1</sub> and 5-HT<sub>1A</sub> receptor signaling.

Psychopharmacology·2026
Same journal

Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apnea.

Psychopharmacology·2026
Same journal

Suicide attempt risk among patients receiving methylphenidate: a retrospective cohort study.

Psychopharmacology·2026
Same journal

Investigating the impact of serotonergic psychedelic drugs, MDMA and ketamine on social cognition in psychiatric disorders: A scoping review.

Psychopharmacology·2026
See all related articles

Nicotine and its analogs enhance cognitive functions like memory and attention by targeting specific nicotinic receptors. These findings support the development of novel nicotinic therapeutics for cognitive disorders.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Nicotine administration has demonstrated cognitive-enhancing effects in both human and animal studies.
  • Nicotinic treatments are under development for various cognitive dysfunctions.

Purpose of the Study:

  • To understand the neurobehavioral underpinnings of nicotinic effects on cognition.
  • To guide the development of effective nicotinic therapeutics.

Main Methods:

  • Review of studies on cognitive functions (attention, learning, memory) affected by nicotinic treatments.
  • Identification of neural substrates, specific receptor targets (e.g., alpha4beta2, alpha7 nicotinic receptors), and brain regions (hippocampus, amygdala).

Main Results:

  • Nicotine and agonists improve working memory, learning, and attention.

Related Experiment Videos

  • Alpha4beta2 and alpha7 nicotinic receptors are crucial for memory.
  • Nicotinic activity in the hippocampus and amygdala is vital for memory function.

    • Conclusions:

    • Understanding the specific mechanisms of nicotinic action aids in developing targeted treatments.
    • Nicotinic therapies, potentially combined with other treatments, show promise for cognitive impairments like Alzheimer's disease and schizophrenia.
    • Further research is needed to establish the efficacy and safety of these nicotinic treatments.