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Updated: Feb 9, 2026
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Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
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Properties of murine (CD8+)CD27- T cells
Paul A Baars1, Sophie Sierro, Ramon Arens
1Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands. p.a.baars@amc.uva.nl
European Journal of Immunology
|October 13, 2005
Summary
In mice, CD27 is lost from CD8+ T cells after repeated antigen exposure, indicating effector memory cells. These CD27- cells express cytotoxic molecules like granzyme B.
Area of Science:
- Immunology
- T cell biology
Background:
- CD27 expression on CD8+ T cells is linked to effector functions in humans.
- Understanding CD27's role in murine CD8+ T cells is crucial for comparative immunology.
Purpose of the Study:
- To investigate the phenotype and distribution of CD27- CD8+ T cells in mice.
- To determine the conditions under which CD27 is downregulated on murine CD8+ T cells.
Main Methods:
- Flow cytometry analysis of CD8+ T cells in various tissues.
- Tracking antigen-specific CD8+ T cells following viral infections (influenza and MCMV).
Main Results:
- Murine CD8+CD27- T cells are a distinct population found in blood and non-lymphoid organs, not lymph nodes.
- Loss of CD27 expression correlates with effector functions, including granzyme B and perforin, after viral infections.
- CD27 is downregulated on CD8+ T cells following repetitive antigenic stimulation.
Conclusions:
- CD27 serves as a marker for terminally differentiated effector CD8+ T cells in mice.
- CD27- CD8+ T cells represent a memory population expressing cytotoxic effector molecules.
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