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Updated: Aug 15, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Is GAD2 on chromosome 10p12 a potential candidate gene for morbid obesity?
Hemant K Tiwari1, Luigi Bouchard, Louis Pérusse
1Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham 35294, USA. htiwari@UAB.edu
Abstract:
Morbidly obese individuals represent one of the fastest growing subpopulations of obese individuals. Thus, it is of significant interest to broaden our understanding of the potential genetic causes of this public health concern. A recent study investigated a role of positional candidate gene GAD2 (the gene for glutamic acid decarboxylase) in the development of morbid obesity. This commentary carefully examines the genetic and functional arguments for and against the GAD2 gene as an influential gene for obesity. Also discussed are additional research questions that merit inquiry when further evaluating this genetic variant as a putative contributor to human obesity.
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