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Updated: Aug 15, 2026

Mapping Infant Immunity with Minimal Input: Integrative Single-Cell and Multiomic Profiling
Published on: April 3, 2026
Hunting for immune response regulatory genes: vaccination studies in infant twins
Melanie J Newport1, Tessa Goetghebuer, Arnaud Marchant
1Department of Medicine, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PS, UK. m.j.newport@bsms.ac.uk
Abstract:
The contribution of twin studies towards unraveling the complex mechanisms of multifactorial diseases is increasingly recognized. Recent twin studies using infant vaccination as a model for infectious diseases have confirmed the importance of host genetic factors as major regulators of the immune response. A combination of twin-based family studies and population-based association studies should lead to the identification of the specific genes involved. These genes and their products have the potential to be developed as targets for novel therapeutic and prophylactic agents against infectious diseases.
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