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Skin function parameters in intensive-care patients.

Matthias Fischer1, Christian Donath, Joachim Radke

  • 1Department of Dermatology and Venereology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany. matthias.fischer@medizin.uni-halle.de

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|October 14, 2005
PubMed
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Transepidermal water loss (TEWL) and skin surface pH were measured in intensive care patients. Higher pH values were linked to developing systemic inflammatory response syndrome or sepsis, but TEWL did not predict prognosis.

Area of Science:

  • Dermatology
  • Intensive Care Medicine
  • Critical Care

Background:

  • Skin barrier function is crucial in critical care settings.
  • Assessing skin integrity aids in patient management.
  • Transepidermal water loss (TEWL) and skin pH are key indicators of skin barrier function.

Purpose of the Study:

  • To investigate transepidermal water loss (TEWL) and skin surface pH in intensive care unit (ICU) patients.
  • To determine the relationship between these parameters and patient prognosis.
  • To evaluate the feasibility of bedside measurements in the ICU.

Main Methods:

  • A cohort of 40 ICU patients (22 male, 18 female) was studied.
  • TEWL and pH were measured at admission and at 24, 96, and 168 hours.

Related Experiment Videos

  • Measurements were taken on the forehead, volar forearm, paraumbilical, and ventral thigh areas under standardized conditions.

    • Main Results:

    • Forehead measurements showed elevated TEWL compared to other sites.
    • No significant changes in mean TEWL were observed during the study period.
    • Patients who developed systemic inflammatory response syndrome (SIRS) or sepsis exhibited higher mean pH values throughout the study.
    • TEWL at admission did not significantly influence patient prognosis.

    Conclusions:

    • Bedside measurement of TEWL and skin pH in the ICU is feasible and yields reproducible results.
    • Skin surface pH may serve as a relevant biomarker for specific patient subgroups in critical care.
    • TEWL and pH measurements may offer insights into disease progression or complications in certain ICU populations.