Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interconversion studies of betamethasone acetate polymorphs.

Xue Ke1, QiNeng Ping, Hua Shi

  • 1Department of Pharmaceutics, China Pharmaceutical University, Nanjing, P.R. of China.

Drug Development and Industrial Pharmacy
|October 14, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CMA-Nano: A DNA Methylation Detection Method for Nanopore Sequencing Data Based on a Cross-Modal Attention Mechanism.

ACS omega·2026
Same author

Regulation Roles of p-Block Elements in Lithium Layered Oxide Cathodes: Recent Progress and Perspectives.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Size-dependent reliability of empirical potentials for global optimization of Pt-Cu bimetallic clusters.

Nanoscale·2026
Same author

Nuclear basket localized proteasomes maintain circadian period through nuclear TOC1 proteolysis.

bioRxiv : the preprint server for biology·2026
Same author

The gut-bone axis: impact of diet on gut microbiome and osteoporosis.

Bone research·2026
Same author

CataCon: a contrastive graph representation learning framework for catalyst prediction.

Journal of cheminformatics·2026

The study investigated Betamethasone Acetate (BA) polymorphs, finding an enantiotropic relationship between forms II, Ialpha, and Ibeta. Form II is the most stable polymorph when BA is suspended in water.

Area of Science:

  • Pharmaceutical Science
  • Solid-State Chemistry

Background:

  • Betamethasone Acetate (BA) is a corticosteroid with potential for polymorphism.
  • Understanding polymorph stability is crucial for drug formulation and efficacy.

Purpose of the Study:

  • To investigate the polymorph interconversions of Betamethasone Acetate (BA).
  • To determine the most stable polymorph of BA under various pharmaceutical conditions.

Main Methods:

  • Differential Scanning Calorimetry (DSC)
  • Thermogravimetric Analysis (TGA)
  • X-ray Powder Diffraction (XRPD)

Main Results:

  • Identified three enantiotropic polymorphs of BA: form II, Ialpha, and Ibeta.
  • Established the interconversion pathways between these polymorphs under grinding, heating, and aqueous suspension.

Related Experiment Videos

  • Form II was identified as the most thermodynamically stable polymorph in aqueous suspension.

    • Conclusions:

    • Betamethasone Acetate exhibits enantiotropic polymorphism.
    • Form II is the preferred polymorph for formulations involving aqueous suspension due to its superior stability.