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Updated: Aug 15, 2026

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
Published on: March 29, 2019
Chemo-inducible gene therapy
James J Mezhir1, Hank Schmidt, Bakhtiar Yamini
1Department of Surgery, University of Chicago Hospitals, Chicago, Illinois 60637, USA.
Abstract:
Chemo-inducible cancer gene therapy is a potential new treatment for solid tumors that may in part enhance the anti-tumor effects of chemotherapy while minimizing toxicity. This approach combines viral vectors expressing cytotoxic transgenes that can be transcriptionally activated by DNA-damaging agents. The development of chemo-inducible gene therapy has numerous implications for the treatment of both localized and metastatic disease in patients with solid tumors.
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