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Updated: Aug 15, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
Published on: October 22, 2014
The ankle-brachial blood pressure index as a risk indicator of generalized atherosclerosis
Jirí Spácil1, Jaroslava Spácabilová
1IIIrd Medical Clinic, General Faculty Hospital and First Medical Faculty, and Charles University, Department of Angiology, Institute for Postgraduate Medical Education, Prague, Czech Republic. spacil.jiri@vfn.cz
Insights
A simple ankle-brachial blood pressure index (ABI) test can identify individuals at high risk for cardiovascular disease. A low ABI score indicates atherosclerosis and predicts future heart attacks and strokes, even in those without traditional risk factors.
Area of Science:
- Vascular Medicine
- Cardiology
- Preventive Medicine
Background:
- Traditional cardiovascular disease risk assessments have limitations.
- There is a need for simple, cost-effective screening methods.
- Peripheral artery disease is an indicator of systemic atherosclerosis.
Purpose of the Study:
- To evaluate the ankle-brachial blood pressure index (ABI) as a screening tool for cardiovascular disease.
- To determine the association between low ABI and cardiovascular event risk.
- To highlight the clinical utility of ABI in risk stratification.
Main Methods:
- Measurement of blood pressure in the lower extremities (ankles) and upper extremities (brachial).
- Calculation of the ankle-brachial blood pressure index (ABI) ratio.
- Analysis of ABI values in relation to cardiovascular disease risk.
Main Results:
- A reduced ABI (≤ 0.9) signifies atherosclerosis in lower extremity arteries.
- Low ABI is independently associated with a significantly increased risk of myocardial infarction and stroke.
- ABI assessment is a practical clinical examination for middle-aged and elderly individuals.
Conclusions:
- The ankle-brachial blood pressure index (ABI) is a valuable, inexpensive tool for identifying individuals at elevated cardiovascular risk.
- Patients with an ABI of 0.9 or less warrant consideration for secondary preventive therapies.
- Routine ABI screening can improve cardiovascular risk assessment and patient management.
Abstract:
Contemporary methods of assessment of possible cardiovascular disease based on traditional risk factors are not perfect. Therefore new ways are sought. Simple and inexpensive methods include assessment of the blood pressure on the lower extremities above the ankles. The finding of a reduced ratio of the ankle-brachial blood pressure index (ABI) indicates atherosclerosis of the lower extremity arteries. ABI values of 0.9 or less are associated with a significantly increased risk of cardiovascular diseases (in particular myocardial infarction and stroke) that is independent of other risk factors. ABI assessment is a simple clinical examination and should be performed in middle-aged and elderly subjects with a medium and high cardiovascular risk in order to define more accurately their health status. Patients with reduced ABI of 0.9 or less are candidates for secondary preventive treatment for cardiovascular disease.
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