Related Experiment Video
Updated: Aug 15, 2026
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Hippocampal volume as a predictor of short-term ECT outcomes in older patients with depression
Ruby E Lekwauwa1, Douglas R McQuoid, David C Steffens
1Division of Geriatric Psychiatry, Duke Univ. Medical Center, Box 3903, Durham, NC 27710, USA.
Objective:
The authors examined the relationship between hippocampal volume and acute electroconvulsive therapy (ECT) outcomes.
Methods:
Depression was measured by Montgomery-Asberg Depression Rating Scale (MADRS) scores, and hippocampal volume was assessed by magnetic resonance imaging.
Results:
After controlling for baseline MADRS score, larger right-hippocampal volume was associated with higher MADRS scores after an index course of ECT.
Conclusion:
These results are the converse of those obtained in a study assessing the relationship between hippocampal volume and pharmacotherapy. The findings suggest a need for further study in this area.
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