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Updated: Jun 20, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 7, 2010
A fine-scale map of recombination rates and hotspots across the human genome
Simon Myers1, Leonardo Bottolo, Colin Freeman
1Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.
Abstract:
Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.
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