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Updated: Aug 15, 2026
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
In vitro antitumor activity of cyanidin-3-O-beta-glucopyranoside
Carmela Fimognari1, Fausto Berti, Michael Nusse
1University of Bologna, Italy. carmela.fimognari@unibo.it
Background:
Little is currently known regarding the cancer-preventive potential of cyanidin-3-O-beta-glucopyranoside (Cy-g) apart from its antioxidant activity.
Methods:
We tested Cy-g on Jurkat and HL-60 leukemia cell lines and, to help elucidate whether the effects of Cy-g are specific for cancer cells, also on normal T lymphocytes.
Results:
Cy-g induced apoptosis in all three cell systems, and this indicated that Cy-g was not selective towards leukemia cells. Moreover, Cy-g caused HL-60 differentiation. The induction of apoptosis and cytodifferentiation involved different proteins, thus suggesting that Cy-g-induced apoptosis and cytodifferentiation are two distinct events.
Conclusions:
Although obtained in vitro, our findings indicate that Cy-g possesses some interesting biological properties that should encourage further investigation as regards its chemotherapeutic potential.
