Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

B lymphocytes and systemic sclerosis.

Manabu Fujimoto1, Shinichi Sato

  • 1Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Current Opinion in Rheumatology
|October 15, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of enzyme-linked immunosorbent assays for the detection of myositis-specific autoantibodies against signal recognition particle, nuclear matrix protein 2, and small ubiquitin-like modifier activating enzyme.

Modern rheumatology·2026
Same author

Fatal Pericarditis and Cardiac Tamponade During Selumetinib Treatment for Pericardial Neurofibroma.

The Journal of dermatology·2026
Same author

Author Correction: GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region.

Nature communications·2026
Same author

Focal dermal hypoplasia with clinical features mimicking classic hypohidrotic ectodermal dysplasia and cardiofaciocutaneous syndrome.

European journal of dermatology : EJD·2025
Same author

Cardiovascular complication by COVID-19 infection in SSc patients with anti-RNA polymerase III antibody.

Rheumatology (Oxford, England)·2025
Same author

Clinical and Epidemiological Features of Juvenile-Onset Systemic Sclerosis From a Nationwide Survey in Japan.

The Journal of rheumatology·2025

B cells play a significant role in systemic sclerosis pathogenesis beyond autoantibody production. Targeting B cells and regulators like CD19/CD22 may offer new therapeutic strategies for this autoimmune disease.

Area of Science:

  • Immunology
  • Rheumatology
  • Cell Biology

Background:

  • Systemic sclerosis involves fibrosis and autoimmunity with unclear links between immune activation and clinical symptoms.
  • B cells are increasingly recognized for diverse roles in autoimmunity, including antigen presentation and cytokine production, beyond autoantibody secretion.

Purpose of the Study:

  • To review recent advances in understanding the multifaceted role of B cells in systemic sclerosis.
  • To explore the pathogenic contributions of B cells and their regulatory molecules in systemic sclerosis.

Main Methods:

  • Review of current literature on B cell function in systemic sclerosis.
  • Analysis of B cell homeostasis, including naive and memory B cell populations.
  • Investigation of molecular regulators like CD19 and CD22 in B cell signaling.

Related Experiment Videos

Main Results:

  • Systemic sclerosis patients exhibit altered B cell homeostasis with expanded naive and diminished memory B cells.
  • Memory B cells in systemic sclerosis are chronically activated, potentially due to CD19 overexpression, linked to genetic polymorphisms.
  • B cells from tight-skin mouse models show enhanced CD19 signaling and hyper-reactivity, associated with impaired CD22 function.

Conclusions:

  • B cells possess more significant pathogenic roles in systemic sclerosis than previously understood.
  • Further research is needed to elucidate the molecular mechanisms connecting B cells and fibrosis.
  • B cells and regulators like CD19/CD22 represent promising therapeutic targets for systemic sclerosis.