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Updated: Aug 15, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
Published on: January 28, 2021
[Level and heritability analysis of serum apoA I and apoB100 in twins]
Wen-jing Gao1, Li-ming Li, Wei-hua Cao
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100083, China.
Objective:
To describe the serum level of apoA I and apoB100 in twins, and study the contribution of genetic and environmental effects to them.
Methods:
The researchers used immunoturbidimetric assay (ITA) for quantification of the serum apoA I and apoB100 in 329 monozygotic (MZ) and 173 dizygotic (DZ) twins identified by genotyping. Mx was used to fit a variety of genetic models covering age and sex for the variation of apoA I and apoB100.
Results:
The serum levels were (1.33+/-0.23) g/L for apoA I and (0.75+/-0.19) g/L for apoB100. Model AES fitted apoA I data best and scalar effects sex-limitation model AE fitted apoB100 best. 60% of the variance in apoA I was due to additive effects and 69% in apoB100.
Conclusion:
The heritability of apoA I and apoB100 in this twin study was 60% and 69%.
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