Small intestinal submucosa intracardiac patch: an experimental study
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Updated: Aug 15, 2026
Implantation of hiPSC-derived Cardiac-muscle Patches after Myocardial Injury in a Guinea Pig Model
Published on: March 18, 2019
Michael Rosen1, Eric E Roselli, Cristiano Faber
1Cleveland Clinic Foundation Department of General Surgery, Cleveland, OH 44195, USA.
Abstract:
In this experimental study, small intestinal submucosa was implanted as an atrial prosthesis in calves. Echocardiography and histology showed this to be an impermeable prosthesis that develops a neointimal nonthrombogenic surface making it safe for repair of defects in a low-pressure system. Further study with small intestinal submucosa in an intracardiac position is warranted.
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