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Acute suicidal intoxication with topiramate
Jacek Sein Anand1, Zygmunt Chodorowski, Maria Zbikowska-Bojko
11st Clinic of Internal Diseases and Acute Poisonings, Medical University of Gdańsk, Poland. jsanand@amedec.amg.gda.pl
Przeglad Lekarski
|October 18, 2005
Summary
This is the first reported case of Topamax (topiramate) intoxication in Poland. A 15-year-old experienced agitation, bradykinesia, and bradyphasia after a suicide attempt.
Area of Science:
- Neurology
- Clinical Toxicology
Background:
- Topiramate is an anticonvulsant and migraine prophylactic medication.
- Intentional overdose cases require careful clinical monitoring.
Observation:
- A 15-year-old female ingested 450 mg of Topamax in a suicide attempt.
- Initial medical examination and biochemical tests showed no significant abnormalities.
Findings:
- The patient exhibited agitation that progressed to bradykinesia (slowness of movement) and bradyphasia (slowness of speech).
- These neurological symptoms persisted for approximately 24 hours.
Implications:
- This case highlights the potential for neurological side effects, including bradykinesia and bradyphasia, with significant topiramate overdose.
- It underscores the importance of monitoring for central nervous system effects in cases of topiramate intoxication.