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Related Experiment Videos

[Rofecoxib-related cutaneous vasculitis].

Gilles Defuentes1, Stéphane Lecoules, Gilles Coutant

  • 1Clinique médicale, Hôpital d'Instruction des Armées du Val de Grâce, Paris. gildef@club-internet.fr

Presse Medicale (Paris, France : 1983)
|October 18, 2005
PubMed
Summary

Nonsteroidal anti-inflammatory drugs (NSAIDs), including coxibs, can cause vasculitis. A case study showed drug-induced vasculitis resolved upon withdrawal of ketoprofen and rofecoxib.

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Area of Science:

  • Pharmacology
  • Immunology
  • Dermatology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with approximately 10% of small vessel vasculitis cases.
  • Selective cyclo-oxygenase 2 (COX-2) inhibitors are increasingly implicated in drug-induced vasculitis.

Observation:

  • A 76-year-old male developed vasculitis symptoms attributed to ketoprofen.
  • Symptoms recurred with rofecoxib (a COX-2 inhibitor) and included purpura.
  • Diagnosis of rofecoxib-induced cutaneous vasculitis was confirmed by symptom resolution after drug cessation.

Findings:

  • Coxibs, a class of NSAIDs, are capable of inducing vasculitis.
  • The specific frequency of coxib-induced vasculitis remains undetermined.

Implications:

  • Clinicians should consider coxibs and other NSAIDs in the differential diagnosis of vasculitis.
  • Patient history of NSAID use is crucial for diagnosing drug-induced vasculitis.
  • Discontinuation of the offending NSAID is key to managing drug-induced vasculitis.

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