Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Iron and insulin resistance.

S Fargion1, P Dongiovanni, A Guzzo

  • 1Dipartimento Medicina Interna, Ospedale Maggiore IRCCS, Università di Milano, Milano, Italy. silvia.fargion@unimi.it

Alimentary Pharmacology & Therapeutics
|October 18, 2005
PubMed
Summary

Iron levels impact liver insulin sensitivity. Reducing iron improved insulin receptor function and decreased insulin resistance in patients with non-alcoholic fatty liver disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Research in paediatric dentistry: the paradox of reviews without trials.

European journal of paediatric dentistry·2026
Same author

SIOI Policy on Sugar Intake: Limiting Free Sugars from Earliest Days of Life to Prevent Caries, Specific Non-Communicable Diseases, and Tumors.

European journal of paediatric dentistry·2025
Same author

Effective Prevention & Lifelong health.

European journal of paediatric dentistry·2025
Same author

The European Journal of Paediatric Dentistry achieves Q1 status: a strategic advancement in specialised dental publishing.

European journal of paediatric dentistry·2025
Same author

Liver function in X-linked myotubular myopathy and autosomal dominant centronuclear myopathy: Data of the unite-CNM study.

Journal of neuromuscular diseases·2025
Same author

Paediatric smiles: the power of a multidisciplinary team.

European journal of paediatric dentistry·2025

Area of Science:

  • Hepatology
  • Metabolic Research
  • Endocrinology

Background:

  • Emerging evidence suggests iron influences hepatocyte insulin sensitivity.
  • Iron may interfere with insulin receptor signaling pathways.

Purpose of the Study:

  • Evaluate in vivo iron's effect on insulin resistance and release in non-alcoholic fatty liver disease (NAFLD) patients.
  • Investigate in vitro iron's interaction with insulin sensitivity using HepG2 cells.

Main Methods:

  • Assessed insulin resistance using HOMA-IR.
  • Administered dietary changes and phlebotomy for iron depletion.
  • Utilized desferrioxamine for in vitro iron manipulation.
  • Measured insulin receptor expression and binding.

Related Experiment Videos

Main Results:

  • Diet and phlebotomy significantly reduced HOMA-insulin resistance.
  • Iron depletion with desferrioxamine doubled insulin binding.
  • Iron addition decreased insulin binding, similar to high glucose effects.

Conclusions:

  • Hepatic iron status modulates insulin receptor expression and affinity.
  • Iron influences insulin-dependent gene expression.
  • Iron depletion may improve insulin clearance and reduce insulin resistance in NAFLD.