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Updated: Aug 15, 2026

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
11:31

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella

Published on: November 30, 2018

Probing luminal negative charge in the type 3 ryanodine receptor

Nicholas Pugh1, Fiona C Mead-Savery, W John Coadwell

  • 1The Laboratory of Functional Immunogenetics, The Babraham Institute, Cambridge CB2 4AT, UK.

Biochemical and Biophysical Research Communications
|October 18, 2005
PubMed
Summary

Neomycin blocks potassium current in the type 3 ryanodine receptor (RyR3) from the luminal side. This polycation exhibits higher affinity for RyR3 than RyR2, suggesting altered charge density in the RyR3 pore mouth.

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