Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiovascular risk among men seeking help for erectile dysfunction.

J Frantzen1, T G W Speel, L A Kiemeney

  • 1Radboud University Medical Centre, Nijmegen, the Netherlands. j.frantzen@vumc.nl

Annals of Epidemiology
|October 18, 2005
PubMed
Summary

Erectile dysfunction (ED) was a marker for cardiovascular disease (CVD) before sildenafil, but not after its introduction. The study investigated the link between ED and CVD risk in men.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation and reliability of the Dutch version of the EORTC QLQ-BLM30 module for assessing the health-related quality of life of patients with muscle invasive bladder cancer.

Health and quality of life outcomes·2022
Same author

Role of multidisciplinary team meetings in implementation of chemohormonal therapy in metastatic prostate cancer in daily practice.

Prostate cancer and prostatic diseases·2022
Same author

Corrigendum to "Urinary incontinence and erectile dysfunction in patients with localized or locally advanced prostate cancer: A nationwide observational study".

Urologic oncology·2022
Same author

An epidemiological study of Puccinia punctiformis (Str.) Röhl as a stepping-stone to the biological control of Cirsium arvense (L.) Scop.

The New phytologist·2021
Same author

Histopathological re-evaluations of biopsies in prostate cancer: a nationwide observational study.

Scandinavian journal of urology·2020
Same author

Urinary incontinence and erectile dysfunction in patients with localized or locally advanced prostate cancer: A nationwide observational study.

Urologic oncology·2020

Area of Science:

  • Cardiovascular Medicine
  • Urology
  • Epidemiology

Background:

  • Erectile dysfunction (ED) prevalence and its association with cardiovascular disease (CVD) became a significant clinical concern following sildenafil's introduction.
  • Physicians questioned whether ED serves as an early indicator for underlying CVD.

Purpose of the Study:

  • To investigate the relationship between ED and the risk of developing CVD.
  • To determine if ED remains a sentinel marker for CVD after the widespread availability of sildenafil.

Main Methods:

  • A historical cohort study utilized general practice medical records from the Netherlands.
  • Incident ED cases and controls (men without ED) were identified from a population of 60,000 men aged 35-74 years.
  • CVD incidence was compared between men with and without ED before and after sildenafil's introduction.

Related Experiment Videos

Main Results:

  • The incidence of ED doubled post-sildenafil introduction (5.3 to 10.1 per 1000 men-years).
  • The relative risk of CVD in men with ED was 1.7 before sildenafil (95% CI 0.9-3.3) and 1.1 afterwards (95% CI 0.6-1.8).

Conclusions:

  • ED was a significant marker for CVD risk prior to sildenafil's market entry.
  • The association between ED and CVD risk diminished significantly after sildenafil became available, suggesting ED is no longer a reliable CVD sentinel in this context.