Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Near-threshold field stimulation: intramural versus surface activation.

Christian W Zemlin1, Sergey Mironov, Arkady M Pertsov

  • 1Deparment Pharmacology, SUNY Upstate Medical University, 750 E Adams Street, 13210 Syracuse, NY, USA.

Cardiovascular Research
|October 18, 2005
PubMed
Summary

Electrical cardioversion

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolution of Energy Sources in Surgical Ablation of Atrial Fibrillation: Current Technology and Future Directions.

Reviews in cardiovascular medicine·2026
Same author

Polymer-Infiltrated Ceramic Network Versus Smart Bioactive Self-Curing Composite for Cervical Restorations in Professional Ballet Dancers: A 24-Month Split-Mouth Randomized Controlled Trial.

Medicina (Kaunas, Lithuania)·2026
Same author

Noninvasive optogenetic induction of cardiac arrhythmias alters systemic hemodynamics in mice.

Science advances·2026
Same author

Mechanisms of atrial fibrillation in mitral regurgitation patients: Insights from noninvasive electrocardiographic imaging.

Journal of electrocardiology·2026
Same author

Polyethylene terephthalate cubic nonlinearity coefficient measurement with a modified Z-scan technique.

Applied optics·2025
Same author

Biomarkers of postoperative cardiac surgery-associated acute kidney injury: Narrowing the field.

JTCVS open·2025

Area of Science:

  • Cardiac Electrophysiology
  • Biophysics
  • Medical Imaging

Background:

  • The precise mechanism of how electric fields terminate cardiac arrhythmias remains unclear.
  • Current methods primarily assess epicardial electrical activity, with limited insight into transmural effects.
  • Understanding deep myocardial electrical field effects is crucial for optimizing defibrillation strategies.

Purpose of the Study:

  • To differentiate between intra-myocardial and surface electrical field effects during cardioversion.
  • To investigate the initiation sites of electrical activation within the myocardium under field stimulation.
  • To elucidate the role of tissue properties in mediating electrical field responses.

Main Methods:

  • Optical mapping of pig ventricular wall slabs using di-4-ANNEPS dye.
  • Application of uniform transmural electric fields via planar mesh electrodes.
  • Simultaneous recording of electrical activity from epicardial and endocardial surfaces.
  • Computational modeling using a bidomain Luo-Rudy model.

Main Results:

  • Early myocardial activation initiated deep within the tissue, not at the expected cathodal surface.
  • Activation sites were found to be closer to the endocardium than the epicardium.
  • Computational models reproduced these findings when incorporating resistive heterogeneities.

Conclusions:

  • Surface polarization has a minimal role in weak field stimulation during diastole.
  • Intramural virtual electrodes, generated by weak fields, can initiate intra-myocardial excitation.
  • Tissue resistivity heterogeneities likely contribute to the strength of these intramural virtual electrodes.

Related Experiment Videos