Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The intracrine hypothesis: an update.

Richard N Re1, Julia L Cook

  • 1Research Division, Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA. rre@ochsner.org

Regulatory Peptides
|October 18, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Look Back at the Second Generation of Ochsner Research.

Ochsner journal·2024
Same author

Effectiveness and Safety of Enteric-Coated vs Uncoated Aspirin in Patients With Cardiovascular Disease: A Secondary Analysis of the ADAPTABLE Randomized Clinical Trial.

JAMA cardiology·2023
Same author

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease.

The New England journal of medicine·2021
Same author

Rationale and Design of the Aspirin Dosing-A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE) Trial.

JAMA cardiology·2020
Same author

Edward D. Frohlich, MD: September 10, 1931-August 16, 2019.

Hypertension (Dallas, Tex. : 1979)·2019
Same author

Association of Post-Traumatic Stress Disorder Symptoms Following Hurricane Katrina With Incident Cardiovascular Disease Events Among Older Adults With Hypertension.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2018
Same journal

The merger of Regulatory Peptides and Peptides.

Regulatory peptides·2014
Same journal

WITHDRAWN: Effects of centrally-injected glucagon-like peptide-2 on gastric mucosal blood flow in rats; possible mechanisms.

Regulatory peptides·2014
Same journal

Hypothalamic-pituitary thyroid axis alterations in female mice with deletion of the neuromedin B receptor gene.

Regulatory peptides·2014
Same journal

Resistin induces lipolysis and suppresses adiponectin secretion in cultured human visceral adipose tissue.

Regulatory peptides·2014
Same journal

Insulin-like growth factor-1 inhibits colonic smooth muscle cell apoptosis in diabetic rats with colonic dysmotility.

Regulatory peptides·2014
Same journal

Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats.

Regulatory peptides·2014
See all related articles

The intracrine action hypothesis explains how intracellular peptide hormones and growth factors function. Recent findings support this theory, demonstrating consistent synthesis and function characteristics for these molecules.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Endocrinology

Background:

  • Intracrine action describes intracellular functions of peptide hormones, growth factors, signaling enzymes, and DNA-binding proteins.
  • These molecules can act within their cells of synthesis or target cells.
  • Despite structural diversity, intracrine moieties share common synthesis and functional traits.

Purpose of the Study:

  • To describe the intracrine action hypothesis.
  • To discuss recent experimental evidence supporting the hypothesis.
  • To validate predictions derived from the intracrine theory.

Main Methods:

  • Literature review of the intracrine action hypothesis.
  • Analysis of recent experimental findings related to intracrine action.

Related Experiment Videos

  • Comparison of experimental results with theoretical predictions.

    • Main Results:

    • The intracrine hypothesis provides a framework for understanding intracellular signaling.
    • Recent experimental data align with predictions made by the intracrine theory.
    • Evidence supports the conserved characteristics of synthesis and function for intracrine molecules.

    Conclusions:

    • The intracrine action hypothesis is supported by new experimental findings.
    • The theory offers a valuable perspective on the intracellular roles of peptides and proteins.
    • Further research is warranted to fully elucidate intracrine mechanisms.