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CD8+ T cells in autoimmunity.

Ulrich Walter¹, Pere Santamaria

¹Julia McFarlane Diabetes Research Centre and Department of Microbiology and Infectious Diseases, Faculty of Medicine, The University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.

Current Opinion in Immunology

|October 18, 2005

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CD8(+) T cells, previously overlooked, are now recognized for their significant role in initiating, progressing, and regulating autoimmune diseases. These cells can directly kill targets or modulate immune responses through cytokine and chemokine secretion.

Area of Science:

Immunology
Autoimmunity

Background:

CD8(+) T cells are increasingly implicated in autoimmune diseases.
Their roles in autoimmunity were previously underestimated.

Purpose of the Study:

To review the diverse functions of CD8(+) T cells in autoimmune responses.
To highlight recent advances in understanding their activation and recruitment.

Main Methods:

Review of current literature on CD8(+) T cell involvement in autoimmunity.
Analysis of mechanisms of CD8(+) T cell activation, recruitment, and effector functions.

Main Results:

CD8(+) T cells contribute to autoimmune initiation, progression, and regulation.
Mechanisms include direct cytotoxicity, cytokine secretion, and chemokine release.

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Autoreactive CD8(+) T cells can also dampen autoimmune responses.

Conclusions:

CD8(+) T cells play multifaceted roles in autoimmunity.
Advances provide mechanistic insights into their involvement.
Further research is warranted to explore therapeutic strategies targeting these cells.