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Elevated interleukin-12 and CXCL10 in subacute sclerosing panencephalitis

Güher Saruhan-Direskeneli1, Candan Gürses, Veysi Demirbilek

  • 1Department of Physiology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey. gsaruhan@istanbul.edu.tr

Cytokine
|October 18, 2005
PubMed

Insights

Measles virus (MV) infection impairs immune responses in subacute sclerosing panencephalitis (SSPE). Elevated cytokines like IL-12 and IL-10 in SSPE patients suggest a complex immune dysregulation.

Area of Science:

  • Neuroimmunology
  • Virology
  • Infectious Diseases

Background:

  • Subacute sclerosing panencephalitis (SSPE) is a severe neurological complication of measles virus (MV) infection.
  • MV-associated immunosuppression is implicated in SSPE pathogenesis, potentially due to cytokine dysregulation.

Purpose of the Study:

  • To investigate cytokine and chemokine profiles in cerebrospinal fluid (CSF) and serum of SSPE patients.
  • To elucidate the role of immune mediators in MV-induced immunosuppression and SSPE pathogenesis.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify 11 cytokines and chemokines in CSF and serum.
  • Patient cohorts included 60 SSPE cases, 36 infectious/inflammatory neurological disease (IN) cases, and 28 non-inflammatory neurological disease (NIN) cases.

Main Results:

  • Elevated levels of IL-12 p70+p40 and IL-10 were observed in SSPE patients' CSF and serum compared to the NIN group.
  • Significantly higher CXCL10 levels were found in SSPE CSF, while CXCL8 was elevated in SSPE serum compared to NIN.
  • No significant differences were detected for IFN-gamma, IFN-alpha, IL-17, IL-18, IL-4, CCL2, or CCL5 between groups.

Conclusions:

  • The findings suggest impaired immune responses against MV in SSPE, despite the presence of some T cell/Th1-inducing stimuli.
  • Specific cytokine and chemokine alterations in SSPE indicate a complex immune dysregulation contributing to disease pathogenesis.

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