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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Visual loss as a first sign of adult-type chronic myeloid leukemia in a child
Günther Rudolph1, Christos Haritoglou, Irene Schmid
1Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany. guenther.rudolph@med.uni-muenchen.de
Purpose:
To report the unusual case of retinal leukemic infiltration in a child with adult-type chronic myelocytic leukemia.
Design:
Interventional case report.
Methods:
Complete ophthalmologic examination, including visual acuity measurement and funduscopy. The diagnosis was established by blood cell counts and confirmed by a positive Philadelphia-chromosome translocation (t [9,22]). Treatment consisted of hydroxyurea and stem-cell transplantation.
Results:
After therapy, complete regression of the retinal lesion was observed with full recovery of visual acuity.
Conclusion:
This case underlines the importance of interdisciplinary cooperation between ophthalmologists and pediatric oncologists in the diagnosis and treatment of this disease.
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