Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conduction abnormalities in nonischemic dilated cardiomyopathy: basic mechanisms and arrhythmic consequences.

Fadi G Akar1, Gordon F Tomaselli

  • 1Division of Cardiology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.

Trends in Cardiovascular Medicine
|October 18, 2005
PubMed
Summary

Conduction abnormalities in nonischemic dilated cardiomyopathy contribute to life-threatening arrhythmias. This review explores underlying cellular and molecular mechanisms, differentiating them from ischemic heart failure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generation of induced pluripotent stem cell (JHUi009-A) and isogenic control (JHUi009-A-1) lines from a patient with vascular Ehlers-Danlos syndrome (vEDS) harboring a pathogenic c.2456G > A in COL3A1.

Stem cell research·2026
Same author

Cardiac STIM1 deficiency triggers mitochondrial fission to impair electrophysiological function and exacerbate post-MI remodeling.

Heart rhythm·2026
Same author

Molecular Imaging of Collagen Turnover in Myocardial Infarction.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Combined Analysis of Cardiac Repolarization Entropy and Magnetic Resonance Imaging Enhances Risk Stratification of Patients Receiving a Primary-Prevention ICD.

JACC. Clinical electrophysiology·2026
Same author

Molecular Imaging of Collagen Turnover in Myocardial Infarction.

bioRxiv : the preprint server for biology·2026
Same author

Endothelial Rho kinase controls blood vessel integrity and angiogenesis.

Cardiovascular research·2025

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Research

Background:

  • Heart failure elevates the risk of sudden cardiac death due to ventricular tachyarrhythmias.
  • Altered repolarization is implicated in arrhythmogenic substrate and trigger formation across multiple biological levels.
  • Research has extensively studied conduction abnormalities in ischemic heart disease, but less so in nonischemic dilated cardiomyopathy.

Purpose of the Study:

  • To investigate the role of conduction abnormalities in the development of arrhythmias within nonischemic dilated cardiomyopathy.
  • To elucidate the cellular and molecular mechanisms driving these conduction changes.
  • To compare and contrast conduction slowing in nonischemic versus ischemic heart failure.

Main Methods:

  • Review of existing literature on heart failure, arrhythmias, and conduction abnormalities.

Related Experiment Videos

  • Analysis of cellular and molecular mechanisms, including myocyte excitability, extracellular matrix, and cell-to-cell coupling.
  • Comparative analysis of conduction properties in ischemic and nonischemic heart failure models.

    • Main Results:

    • Conduction abnormalities are a significant factor in arrhythmia genesis in nonischemic dilated cardiomyopathy.
    • Mechanisms involve altered myocyte excitability, extracellular matrix remodeling, and impaired cell-to-cell communication.
    • Conduction slowing in nonischemic heart failure differs mechanistically from that observed in ischemic heart disease.

    Conclusions:

    • Conduction abnormalities play a critical role in the arrhythmogenesis of nonischemic dilated cardiomyopathy.
    • Understanding these specific mechanisms is crucial for developing targeted antiarrhythmic therapies.
    • Distinguishing between ischemic and nonischemic heart failure mechanisms is vital for effective treatment strategies.