Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interferon and the central nervous system.

Nachum Dafny1, Pamela B Yang

  • 1Department of Neurobiology and Anatomy, The University of Texas, Medical School, P.O. Box 20708, Houston, Texas 77225, USA. Nachum.Dafny@uth.tmc.edu

European Journal of Pharmacology
|October 18, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential Impact of Serotonin Signaling Methylphenidate on Young versus Adult: Insights from Behavioral and Dorsal Raphe Nucleus Neuronal Recordings from Freely Behaving Rats.

International journal of molecular sciences·2024
Same author

Differential Roles of Key Brain Regions: Ventral Tegmental Area, Locus Coeruleus, Dorsal Raphe, Nucleus Accumbens, Caudate Nucleus, and Prefrontal Cortex in Regulating Response to Methylphenidate: Insights from Neuronal and Behavioral Studies in Freely Behaving Rats.

International journal of molecular sciences·2024
Same author

Dopamine, Norepinephrine and Serotonin Participate Differently in Methylphenidate Action in Concomitant Behavioral and Ventral Tegmental Area, Locus Coeruleus and Dorsal Raphe Neuronal Study in Young Rats.

International journal of molecular sciences·2023
Same author

Methylphenidate induces a different response in the dorsal raphe as compared to ventral tegmental area and locus coeruleus: behavioral and concomitant neuronal recordings in adult rats.

Journal of neural transmission (Vienna, Austria : 1996)·2023
Same author

Immunotherapy as a treatment to confront the ongoing opioid epidemic- A review.

Journal of cellular and molecular immunology·2023
Same author

Methylphenidate cross-sensitization with amphetamine is dose dependent but not age dependent.

Behavioural brain research·2022
Same journal

Astaxanthin inhibits platelet-mediated thrombosis via suppression of bidirectional αIIbβ3 signaling.

European journal of pharmacology·2026
Same journal

Repurposing of alogliptin to mitigate experimentally-induced ulcerative colitis and its associated pulmonary injury in rats through regulating inflammatory, necroptotic, and ER stress pathways.

European journal of pharmacology·2026
Same journal

Erianin ameliorates liver fibrosis through the PRDX3/NLRX1 axis.

European journal of pharmacology·2026
Same journal

4-Octyl itaconate attenuates renal calculi formation by inhibiting ferroptosis and oxidative stress via the Nrf2-HO-1/SLC7A11 axis.

European journal of pharmacology·2026
Same journal

VER155008 rescues cognitive impairment in P301S tauopathy mice by promoting HSPA8-mediated lipophagy.

European journal of pharmacology·2026
Same journal

Okanin alleviates osteoarthritis by suppressing oxidative stress and pyroptosis via Nrf2/HO-1 activation.

European journal of pharmacology·2026
See all related articles

Interferons (IFNs) are natural antiviral proteins that modulate immunity and brain function. These crucial molecules link the central nervous system, immune system, and endocrine system, impacting health and disease.

Area of Science:

  • Neuroimmunology
  • Endocrinology
  • Virology

Background:

  • Interferons (IFNs) are natural antiviral substances discovered for their role in viral replication interference.
  • IFNs are produced by various immune and neural cells, including monocytes, macrophages, T-lymphocytes, neurons, and glia.
  • IFNs are classified into three main types: alpha, beta, and gamma.

Purpose of the Study:

  • To explore the multifaceted roles of interferons (IFNs) beyond their antiviral properties.
  • To elucidate the neuro-immune-endocrine regulatory functions of IFNs, particularly alpha-IFN.
  • To highlight the therapeutic applications of IFNs in various diseases.

Main Methods:

  • Review of existing literature on interferon discovery and characterization.

Related Experiment Videos

  • Analysis of studies detailing IFN synthesis, secretion, and cellular targets.
  • Examination of research on alpha-IFN's effects on the central nervous system and endocrine system.

    • Main Results:

    • IFNs exhibit profound effects on immunity, cell proliferation, and neurophysiological activities.
    • Alpha-IFN directly impacts the brain by activating hypothalamic neurons and regulating the hypothalamic-pituitary-adrenocortical axis.
    • IFNs act as mediators connecting the central nervous system, immune system, and endocrine system, influencing pain, temperature, and appetite regulation.
    • Alpha-IFN administration activates sympathetic nerves linked to the immune system.

    Conclusions:

    • Interferons are critical regulators of neuro-immune-endocrine interactions.
    • IFNs possess significant therapeutic potential, utilized in treating hematologic malignancies, infectious diseases, and autoimmune disorders.
    • Further research into IFN mechanisms can unlock novel therapeutic strategies.