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Updated: Aug 15, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Polycystic kidney disease

Pamela J Fall1, L Michael Prisant

  • 1Section of Hypertension and Clinical Pharmacology, Medical College of Georgia, Augusta, GA 30912, USA.

Journal of Clinical Hypertension (Greenwich, Conn.)
|October 18, 2005
PubMed

Insights

Polycystic kidney disease (PKD) is an inherited disorder causing cysts in the kidneys. Early diagnosis before age 30 is linked to poorer kidney survival, highlighting the need for timely intervention.

Area of Science:

  • Nephrology
  • Genetics
  • Internal Medicine

Background:

  • Polycystic kidney disease (PKD) is an inherited systemic disorder.
  • Characterized by multiple cyst development in kidneys and other organs.
  • Often diagnosed after age 30, but earlier diagnosis correlates with worse renal survival.

Purpose of the Study:

  • To summarize the key aspects of polycystic kidney disease.
  • To highlight diagnostic indicators and genetic underpinnings.
  • To outline clinical manifestations and management strategies.

Main Methods:

  • Review of clinical presentation and diagnostic approaches.
  • Identification of genetic mutations (PKD1, PKD2) associated with cyst formation.
  • Analysis of common symptoms and complications.

Main Results:

  • Radiographic procedures are primary diagnostic tools.
  • Mutations in PKD1 or PKD2 genes cause cyst formation.
  • Common symptoms include flank pain, hematuria, and hypertension.

Conclusions:

  • PKD is a leading cause of end-stage renal disease.
  • Blood pressure management is crucial, targeting <130/80 mm Hg.
  • Angiotensin-converting enzyme inhibitors are recommended treatments.

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