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Related Experiment Videos

Bone marrow-derived cells in mouse and human cornea.

Satoru Yamagami1, Tomohiko Usui, Shiro Amano

  • 1Department of Corneal Tissue Regeneration, Tokyo University Graduate School of Medicine, Tokyo, Japan. syamagami-tky@umin.ac.jp

Cornea
|October 18, 2005
PubMed
Summary
This summary is machine-generated.

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Bone marrow-derived cells, including dendritic cells and macrophages, are found in the cornea. Their distribution and types differ between human and mouse corneas, and from other human tissues, suggesting immune roles.

Area of Science:

  • Immunology
  • Ophthalmology
  • Cell Biology

Background:

  • Bone marrow-derived cells play crucial roles in immune surveillance.
  • The cornea's immune cell distribution is vital for ocular surface health.
  • Understanding these cells aids in diagnosing and treating corneal diseases.

Purpose of the Study:

  • To review and compare the distribution of bone marrow-derived cells in human and mouse corneas.
  • To compare corneal immune cell distribution with that in human skin and oral mucosa.
  • To elucidate the roles of these cells in ocular surface immunity.

Main Methods:

  • Review of experimental data on cell distribution in corneas, skin, and oral mucosa.
  • Analysis of major histocompatibility complex (MHC) class II expression on dendritic cells (DC).

Related Experiment Videos

  • Identification of monocyte (Mo)/macrophage (MPhi) lineage cells using specific markers.

    • Main Results:

    • Mouse cornea contains MHC class II-negative DCs in the epithelium and varying MHC class II expression in the stroma.
    • Human cornea shows MHC class II-positive myeloid DCs and Mo/MPhi lineage cells in epithelium and stroma.
    • Cell distribution in human cornea differs significantly from human skin and nasal mucosa.

    Conclusions:

    • Bone marrow-derived cells are present in situ in the normal human cornea.
    • These cells are prepared to respond to foreign antigens and pathogens.
    • They play critical roles in the innate and acquired immunity of the ocular surface.