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Updated: Aug 15, 2026
An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
[Comparison and improvement in the methods of establishing animals model of experimental chronic sinusitis in
Bin Lin1, Hui-Ge Wang, Xin-Qiang Lin
1Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Medicine College, Shantou University, Shantou 515041, China. longzaidahai@sohu.com
Objective:
To compare and improve the methods of establishing animal model of experimental chronic sinusitis in rabbits .
Methods:
Sixty-six New Zealand white rabbits were divided into seven groups: control group, sham-operation group I, sham-operation group II, bacteria inoculation group, ostia-blocked group, ostia-blocked and bacteria inoculation group, incomplete ostium blocked and set-cotton group. The animals were examined by the methods of histology and bacteriology after 42 days.
Results:
The positive rate of chronic inflammation in ostium blocked group was 80%, inoculated staphylococcus group was 100%, incomplete ostium blocked and set-cotton group was 100%, and the other groups were 0%. All infected sinuses displayed signs of moderate or severe chronic inflammation. The cultivated bacteria were mainly opportunistic pathogens. The probability of having abscess in maxillary sinus was high in ostia-blocked and bacteria inoculation group.
Conclusions:
The method of incomplete ostium blockage and set cotton can establish stable chronic sinusitis model, it is a simple and perfect method.
