Related Experiment Video
Updated: Aug 15, 2026

A Model of Chronic Nutrient Infusion in the Rat
Published on: August 14, 2013
[Effects of cadmium on levels of insulin in rats]
Li-Jian Lei1, Tai-Yi Jin, Yuan-Fen Zhou
1School of Public Health, Fudan University, Shanghai 200032, China.
Objective:
To explore the effect of cadmium on insulin in rats.
Methods:
96 of SD rats were administered with cadmium at different doses (0, 50, 100, 200 mg/L) by drinking water for 30 days, 60 days, and 90 days. The levels of insulin, the contents of cadmium in the blood, urine, and tissues (liver, kidney, and pancreas) were determined.
Results:
The level of insulin were decreased in the groups of 100 and 200 mg/L at the 30-day and in the group of 100 mg/L at the 60-day. Cadmium in blood and tissues (liver, kidney, and pancreas) were higher in exposed groups than those in control group. But the contents of cadmium in pancreas are lower than that in kidney and liver.
Conclusion:
It is suggested that cadmium could be accumulated in pancreas. Then it maybe related to the change of the levels of insulin in serum.
Related Concept Videos
Type II Diabetes II: Pathophysiology
Type II Diabetes I: Introduction
Diabetes Mellitus: Type 2 and Gestational
Type I Diabetes II: Pathophysiology
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
