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Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas
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[Effects on development of the testicle in diet-induced obesity rats]
Ai-Jun Yang1, Hong Cui, Yan Cui
1Department of Pediatrics, Beijing Friendship Hospital Affiliate of Capital University of Medical Sciences, Beijing 100050, China.
Objective:
We established diet-induced obesity animal model and observed the influence of obesity on testicle of the male rats.
Methods:
Rats in model group were fed with fat-enriched diet for 6 weeks. We measured the body weight and the testis weight and observed the development of testicle by microscope, and compared with those of control group. Meanwhile, we measured the serum levels of testosterone (T) and estradiol (E2).
Results:
The average body weight in model group rats was higher 29% than that in control group at 6 weeks old, 30% at 9 weeks old. We observed under microscope that most of the convoluted seminiferous tubule developed no good in model group, the 4 layer cells was sparse and the arrangement of them was not in order. The testosterone to estradiol ratios(T/E2) in model group was significant lower then that of control group (P < 0.05).
Conclusion:
The fat-enriched fat diet can induce obesity. It influenced the development of the testicle. This probably related to decrease of the testosterone to estradiol ratios.
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