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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Published on: May 14, 2013

Statin therapy: a potentially useful peri-operative intervention in patients with cardiovascular disease

B M Biccard1, J W Sear, P Foëx

  • 1Clinical Research Fellow, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK. bruce.biccard@nda.ox.ac.uk

Anaesthesia
|October 19, 2005
PubMed

Insights

Peri-operative statin administration improves cardiac outcomes in surgical patients. This cardioprotection, potentially linked to plaque stability, warrants specific recommendations for use, timing, and duration.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Statins offer cardiovascular protection via lipid lowering and pleiotropic effects.
  • Efficacy established in non-surgical cardiovascular disease and acute coronary events.
  • Peri-operative statin use shows promise for cardiac outcomes.

Purpose of the Study:

  • To review the evidence for peri-operative statin administration.
  • To suggest recommendations for peri-operative statin therapy.

Main Methods:

  • Literature review of studies on peri-operative statin use.
  • Analysis of effects on short-term and long-term cardiac outcomes.
  • Consideration of mechanisms like plaque stability.

Main Results:

  • Peri-operative statins improve cardiac outcomes after non-cardiac and coronary bypass graft surgery.
  • Cardioprotection may be independent of hemodynamic effects, possibly due to plaque stabilization.
  • Recommendations for optimal use are proposed.

Conclusions:

  • Peri-operative statin administration is beneficial for cardiac outcomes.
  • Evidence supports specific guidelines for indications, timing, and duration.
  • Consideration of withdrawal effects, safety, and cost-effectiveness is crucial.

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