Related Experiment Video
Updated: Aug 15, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Dengue virus type 3, Brazil, 2002
Rita Maria Ribeiro Nogueira1, Hermann Gonçalves Schatzmayr, Ana Maria Bispo de Filippis
1Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil. rita@ioc.fiocruz.br
Abstract:
During the summer of 2002, Rio de Janeiro had a large epidemic of dengue fever; 288,245 cases were reported. A subset of 1,831 dengue hemorrhagic fever cases occurred. In this study, performed in the first half of 2002, samples from 1,559 patients with suspected cases of dengue infection were analyzed. From this total, 1,497 were obtained from patients with nonfatal cases, and 62 were obtained from patients with fatal cases. By the use of different methods, 831 (53.3%) cases, including 40 fatal cases, were confirmed as dengue infection. When virus identification was successful, dengue virus type 3 (DENV-3) was obtained in 99% of cases. Neurologic involvement was shown in 1 patient with encephalitis, confirmed by the detection of DENV-3 RNA in the cerebrospinal fluid. This explosive epidemic of DENV-3 was the most severe dengue epidemic reported in Brazil since dengue viruses were introduced in 1986.
Related Concept Videos
Yellow Fever
Arboviral Encephalitis
American Trypanosomiasis
Cholera
Diphtheria

