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Related Experiment Videos

Evolutionary rate variation in eukaryotic lineage specific human intronless proteins.

Subhash Mohan Agarwal1

  • 1Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. smagarwal@yahoo.com

Biochemical and Biophysical Research Communications
|October 19, 2005
PubMed
Summary

Mammalia-specific intronless genes evolve rapidly compared to older eukaryotic genes, which undergo negative selection. Protein function influences gene evolution rates, but codon usage shows little difference.

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Area of Science:

  • Genomics
  • Evolutionary Biology
  • Comparative Genomics

Background:

  • Human genome evolution is complex.
  • Intronless genes provide insights into evolutionary patterns.
  • Comparing genes across evolutionary lineages (mammalia, eukaryota, coelomata, bilateria) is crucial.

Purpose of the Study:

  • To analyze the evolutionary patterns of 783 human-mouse orthologous intronless genes.
  • To contrast genes specific to different evolutionary lineages.
  • To understand the general evolution of the human genome.

Main Methods:

  • Examined 783 human-mouse orthologous gene pairs.
  • Analyzed sequence evolution patterns.
  • Compared intronless genes specific to mammalia, eukaryota, coelomata, and bilateria.

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  • Investigated rate variations and functional classification.

    • Main Results:

    • Mammalia-specific intronless genes evolve faster than other eukaryotic lineage-specific intronless genes.
    • Older genes conserved in eukaryota, coelomata, and bilateria evolve slowly and are under negative selection.
    • Protein function impacts gene evolution rates in some cases.
    • Mutational bias is unlikely to be the primary driver of rate differences.

    Conclusions:

    • Mammalia-specific intronless genes exhibit rapid evolution.
    • Evolutionary rate variations are influenced by lineage specificity and protein function.
    • Negative selection acts on older, conserved genes.