Related Experiment Video
Updated: Aug 15, 2026

Transcranial Pulse Stimulation for Alzheimer's Patients
Published on: April 4, 2025
Flow motion pattern differences in the forehead and forearm skin: Age-dependent alterations are not specific for
Ferenc Bari1, Valéria Tóth-Szuki, Ferenc Domoki
1Department of Physiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, Dóm tér 10, Hungary. BARI@phys.szote.u-szeged.hu
Abstract:
Oscillations in laser Doppler signals derived from the forehead and forearm skin were analyzed in 77 healthy probands from 4 various age groups (ranging between 15 and 77 years) and 22 late-onset sporadic Alzheimer's disease (AD) patients. A characteristic pattern of oscillations in the microcirculatory blood flux ( approximately 8 cycles/min, 0.13 Hz) was observed in the forehead skin, the occurrence of which correlated inversely with age (r = 0.80). The occurrence of forehead vasomotion pattern was 100% in the teenagers, whereas it was significantly less in the elderly control subjects (32%) and in the AD patients (18%). Forearm reactive hyperemia was provoked by 1-min occlusion of the brachial artery, and the vascular reactivity was calculated. This phenomenon also proved to be age-dependent, but the process was not related to AD. Our results indicate that the lack of forehead vasomotion reflects aging better than does the forearm vasomotion. Both of these functions are preserved in AD.
Related Concept Videos
Alzheimer Disease l: Introduction
Dementia l: Introduction
Alzheimer Disease ll: Pathophysiology
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The Effect of Aging on Tissues
Alterations in Muscle Tone lll

