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Mouse model for acute bacterial prostatitis in genetically distinct inbred strains.
Johny E Elkahwaji1, Christopher J Ott, Lindsay M Janda
1Division of Urology, Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin, USA. elka@surgery.wisc.edu
Urology
|October 19, 2005
Summary
This study developed a mouse model for bacterial prostatitis. Certain mouse strains showed high susceptibility, indicating genetic factors influence infection risk and paving the way for further research.
Area of Science:
- Urology
- Infectious Diseases
- Genetics
Background:
- Prostatitis affects a significant portion of adult men, with bacterial prostatitis occurring in 2-3% of cases.
- The exact causes of prostatitis are not fully understood, necessitating the development of reliable models for study.
Purpose of the Study:
- To establish a reproducible mouse model for bacterial prostatitis.
- To investigate the genetic factors influencing susceptibility to bacterial prostatitis.
Main Methods:
- Five mouse strains (BALB/c, C3H/HeJ, C3H/HeOuJ, C57BL/6J, and F1 hybrids) were inoculated intraurethrally with Escherichia coli.
- Infection intensity in the bladder and prostate was assessed 5 days post-inoculation.
Main Results:
- C3H/HeJ and C3H/HeOuJ mice developed severe bladder and prostate infections.
- BALB/c, C57BL/6J, and F1 mice showed no significant infections.
- A statistically significant difference (P < 0.01) in infection levels was observed between susceptible and resistant strains.
Conclusions:
- Genetic factors play a crucial role in determining susceptibility to bacterial prostatitis.
- Infection susceptibility appears to be a recessive trait, as indicated by F1 hybrid results.
- This new model will facilitate research into the immunology, genetics, and pathology of bacterial prostatitis.