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[Acute methanol poisoning: about one case].

H Théfenne¹, J Turc, T Carmoi

¹HIA Percy, Laboratoire de biochimie clinique, Clamart.

Annales De Biologie Clinique

|October 19, 2005

Summary

Methanol poisoning can cause metabolic coma and acidosis. Early diagnosis relies on lab tests, as clinical signs are nonspecific. Prompt treatment is crucial to prevent vision loss.

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Area of Science:

Toxicology
Internal Medicine
Emergency Medicine

Background:

Metabolic coma with acidosis and elevated anion gap necessitates thorough etiological investigation.
Clinical presentation of intoxication can be nonspecific in early stages, underscoring the need for laboratory findings.

Observation:

This case highlights the diagnostic utility of measuring methanol and its toxic metabolite, formic acid.
Differential diagnosis includes ethylene glycol poisoning, requiring careful laboratory evaluation.

Findings:

Methanol poisoning is a rare but potentially fatal condition.
Toxicity severity correlates with the degree of metabolic acidosis.
Formic acid accumulation increases the risk of ocular and neurological dysfunction.

Implications:

Early and accurate diagnosis of methanol poisoning is critical.
Prompt correction of metabolic acidosis via antidotal therapy or hemodialysis is essential.
Timely intervention can prevent permanent visual damage and other severe complications.

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